/* OncoReport — Instituto Tresace · CSS */
*, *::before, *::after { box-sizing: border-box; margin: 0; padding: 0; }
:root {
  --verde: #18362E; --verde-m: #2a5247; --verde-c: #3d6e62;
  --cinza: #4F5751; --dourado: #B89C79; --dourado-c: #C7B5A1;
  --creme: #E6E5DA; --creme-e: #d8d7cb; --branco: #F9F8F4;
  --texto: #1a2420; --muted: #6b7573;
  --coral-bg: rgba(184,100,30,.05); --coral-bd: rgba(184,100,30,.12); --coral-tx: #7A4010;
}
body { font-family: 'Jost', sans-serif; background: var(--creme); color: var(--texto); min-height: 100vh; }
.app-shell { display: grid; grid-template-columns: 270px 1fr; grid-template-rows: 70px 1fr; min-height: 100vh; }

/* TOPBAR */
.topbar { grid-column:1/-1; background:var(--verde); display:flex; align-items:center; padding:0 28px; gap:0; border-bottom:1px solid rgba(184,156,121,.2); }
.topbar-logo-wrap { display:flex; align-items:center; padding-right:28px; border-right:1px solid rgba(255,255,255,.1); }
.topbar-logo-img { height:38px; filter:brightness(0) invert(1); opacity:.95; }
.logo-text-fallback { font-family:'Cormorant Garamond',serif; font-size:20px; color:var(--dourado-c); }
.topbar-module { padding-left:28px; display:flex; align-items:center; gap:10px; }
.topbar-module-sep { color:rgba(184,156,121,.4); font-size:18px; }
.topbar-module-name { font-family:'Cormorant Garamond',serif; font-size:18px; color:rgba(255,255,255,.5); }
.topbar-module-sub { font-size:11px; color:var(--dourado-c); letter-spacing:.8px; text-transform:uppercase; }
.topbar-right { margin-left:auto; display:flex; align-items:center; gap:10px; }
.topbar-btn { background:rgba(255,255,255,.07); border:1px solid rgba(255,255,255,.12); color:rgba(255,255,255,.65); padding:7px 16px; border-radius:4px; font-size:12.5px; font-family:'Jost',sans-serif; cursor:pointer; display:flex; align-items:center; gap:6px; transition:all .15s; }
.topbar-btn:hover { background:rgba(255,255,255,.13); color:white; }
.topbar-btn.primary { background:var(--dourado); border-color:var(--dourado); color:var(--verde); font-weight:600; }
.topbar-btn.primary:hover { background:var(--dourado-c); }
.topbar-btn:disabled { opacity:.4; cursor:not-allowed; }
.topbar-alert { background:#B8641E; color:white; border-radius:50%; width:16px; height:16px; font-size:10px; font-weight:700; display:flex; align-items:center; justify-content:center; }

/* SIDEBAR */
.sidebar { background:var(--branco); border-right:1px solid var(--creme-e); padding:20px 0; display:flex; flex-direction:column; gap:2px; overflow-y:auto; }
.sidebar-section { padding:10px 18px 4px; font-size:9.5px; font-weight:600; color:var(--dourado); letter-spacing:1.5px; text-transform:uppercase; margin-top:6px; }
.sidebar-item { margin:0 10px; padding:9px 12px; border-radius:3px; display:flex; align-items:center; gap:10px; cursor:pointer; transition:all .15s; font-size:13px; color:var(--cinza); border:1px solid transparent; }
.sidebar-item:hover { background:var(--creme); color:var(--verde); }
.sidebar-item.active { background:var(--verde); color:var(--dourado-c); font-weight:500; }
.sidebar-item.active i { color:var(--dourado); }
.sidebar-item i { font-size:16px; color:var(--cinza); }
.sidebar-badge { margin-left:auto; background:rgba(184,156,121,.15); color:var(--dourado); font-size:10px; font-weight:600; padding:2px 7px; border-radius:2px; }
.sidebar-badge.alert { background:rgba(184,100,30,.1); color:#B8641E; }
.sidebar-badge.done { background:rgba(24,54,46,.08); color:var(--verde); }
.sidebar-divider { height:1px; background:var(--creme-e); margin:8px 18px; }
.sidebar-patient-card { margin:10px; padding:14px; background:linear-gradient(135deg,var(--verde) 0%,var(--verde-m) 100%); border-radius:4px; border:1px solid rgba(184,156,121,.2); }
.sp-label { font-size:9px; color:var(--dourado); font-weight:600; letter-spacing:1.2px; text-transform:uppercase; margin-bottom:5px; }
.sp-name { font-size:14px; font-weight:500; color:white; font-family:'Cormorant Garamond',serif; }
.sp-info { font-size:11.5px; color:rgba(230,229,218,.7); margin-top:3px; }
.sp-tag { display:inline-block; margin-top:8px; background:rgba(184,156,121,.2); color:var(--dourado-c); font-size:10px; padding:2px 8px; border-radius:2px; }

/* MAIN */
.main { overflow-y:auto; padding:28px 32px; display:flex; flex-direction:column; gap:20px; }

/* STATUS BAR */
.status-bar { display:flex; align-items:center; gap:10px; padding:10px 16px; border-radius:3px; font-size:13px; }
.status-bar.info { background:rgba(24,54,46,.06); color:var(--verde); border-left:3px solid var(--verde); }
.status-bar.success { background:rgba(24,54,46,.08); color:var(--verde); border-left:3px solid var(--dourado); }
.status-bar.error { background:var(--coral-bg); color:var(--coral-tx); border-left:3px solid #B8641E; }
@keyframes spin { to { transform:rotate(360deg); } }
.spin { animation:spin 1s linear infinite; }

/* PROGRESS STEPS */
.progress-steps { display:flex; align-items:center; background:white; border:1px solid var(--creme-e); border-radius:4px; padding:10px 16px; box-shadow:0 1px 4px rgba(24,54,46,.04); }
.step { display:flex; align-items:center; gap:7px; padding:5px 12px; border-radius:3px; font-size:12px; color:var(--muted); white-space:nowrap; }
.step.done { color:var(--verde); } .step.done i { color:var(--dourado); }
.step.active { color:var(--verde); background:rgba(184,156,121,.1); font-weight:500; }
.step i { font-size:14px; }
.step-conn { width:16px; height:1px; background:var(--creme-e); flex-shrink:0; }

/* CARDS */
.card { background:white; border-radius:4px; border:1px solid var(--creme-e); overflow:hidden; box-shadow:0 1px 4px rgba(24,54,46,.04); }
.card-header { padding:15px 20px; border-bottom:1px solid var(--creme-e); display:flex; align-items:center; gap:14px; background:var(--branco); }
.card-icon { width:34px; height:34px; border-radius:3px; display:flex; align-items:center; justify-content:center; font-size:17px; flex-shrink:0; }
.card-icon.verde { background:rgba(24,54,46,.08); color:var(--verde); }
.card-icon.dourado { background:rgba(184,156,121,.12); color:var(--dourado); }
.card-icon.cinza { background:rgba(79,87,81,.08); color:var(--cinza); }
.card-icon.coral { background:var(--coral-bg); color:var(--coral-tx); }
.card-icon.creme { background:var(--creme); color:var(--cinza); }
.card-title { font-size:14px; font-weight:500; color:var(--verde); }
.card-subtitle { font-size:11.5px; color:var(--muted); margin-top:2px; }
.card-body { padding:20px; }
.card-actions { padding:12px 20px; background:var(--branco); border-top:1px solid var(--creme-e); display:flex; align-items:center; gap:10px; }
.ml-auto { margin-left:auto; }

/* CHIPS */
.chip { display:inline-flex; align-items:center; gap:5px; padding:4px 10px; border-radius:2px; font-size:11.5px; font-weight:500; border:1px solid transparent; }
.chip.done { background:rgba(24,54,46,.07); color:var(--verde); border-color:rgba(24,54,46,.12); }
.chip.active { background:rgba(184,156,121,.12); color:#8B6B42; border-color:rgba(184,156,121,.25); }
.chip.pending { background:rgba(79,87,81,.07); color:var(--cinza); border-color:rgba(79,87,81,.12); }
.chip.warning { background:rgba(184,100,30,.08); color:#8B4A14; border-color:rgba(184,100,30,.15); }
.chip i { font-size:13px; }

/* NAV TABS */
.nav-tabs { display:flex; gap:0; border-bottom:1px solid var(--creme-e); margin-bottom:18px; }
.nav-tab { padding:8px 16px; font-size:12.5px; color:var(--muted); cursor:pointer; border:none; background:transparent; font-family:'Jost',sans-serif; border-bottom:2px solid transparent; margin-bottom:-1px; transition:all .15s; }
.nav-tab.active { color:var(--verde); border-bottom-color:var(--dourado); font-weight:500; }
.tab-content { display:none; }
.tab-content.active { display:block; }

/* AUDIO ZONE */
.audio-zone { border:1px dashed var(--dourado-c); border-radius:4px; padding:32px 20px; text-align:center; background:rgba(184,156,121,.04); cursor:pointer; transition:all .2s; }
.audio-zone:hover { border-color:var(--dourado); background:rgba(184,156,121,.08); }
.audio-zone i { font-size:36px; color:var(--dourado); margin-bottom:10px; display:block; }
.audio-zone-title { font-size:14px; font-weight:500; color:var(--verde); }
.audio-zone-sub { font-size:12px; color:var(--muted); margin-top:4px; }
.upload-progress { margin-top:14px; }
.upload-progress-bar { height:4px; background:var(--creme-e); border-radius:2px; overflow:hidden; margin-bottom:6px; }
.upload-progress-fill { height:100%; background:var(--dourado); border-radius:2px; width:0%; transition:width .3s; }

/* RECORD */
.record-btn { width:100%; max-width:320px; padding:14px; border-radius:4px; border:1px solid rgba(184,100,30,.2); background:#FFF5F5; color:#8B4A14; font-size:14px; font-weight:500; font-family:'Jost',sans-serif; cursor:pointer; display:flex; align-items:center; justify-content:center; gap:8px; transition:all .15s; margin:0 auto; }
.record-btn.recording { background:#B8641E; border-color:#B8641E; color:white; animation:pulse 1.5s infinite; }
@keyframes pulse { 0%,100%{opacity:1} 50%{opacity:.8} }
.record-timer { font-family:'Cormorant Garamond',serif; font-size:36px; color:var(--verde); text-align:center; margin-top:12px; }

/* TRANSCRIPT / SUMMARY */
.transcript-box, .summary-box { background:var(--branco); border:1px solid var(--creme-e); border-radius:3px; padding:16px; font-size:13.5px; line-height:1.85; color:var(--texto); min-height:80px; font-weight:300; }
.chip-row { display:flex; gap:8px; flex-wrap:wrap; }

/* TREATMENT TABLE */
.treatment-table { width:100%; border-collapse:collapse; font-size:12.5px; }
.treatment-table th { padding:10px 14px; text-align:left; font-size:10px; font-weight:600; color:var(--muted); letter-spacing:.8px; text-transform:uppercase; border-bottom:1px solid var(--creme-e); background:var(--branco); }
.treatment-table td { padding:11px 14px; border-bottom:1px solid rgba(230,229,218,.6); vertical-align:middle; }
.treatment-table tr:last-child td { border-bottom:none; }
.treatment-table tr:hover td { background:rgba(184,156,121,.03); }
.ev-badge { display:inline-flex; align-items:center; padding:2px 8px; border-radius:2px; font-size:11px; font-weight:600; }
.ev-1a { background:rgba(24,54,46,.08); color:var(--verde); }
.ev-2a { background:rgba(184,156,121,.1); color:#8B6B42; }
.ev-2b { background:rgba(79,87,81,.08); color:var(--cinza); }
.on-label { display:inline-flex; align-items:center; gap:4px; padding:3px 9px; border-radius:2px; font-size:11px; font-weight:600; background:var(--verde); color:var(--dourado-c); }
.off-label { display:inline-flex; align-items:center; gap:4px; padding:3px 9px; border-radius:2px; font-size:11px; background:var(--creme); color:var(--cinza); }

/* VALUE SCORES */
.score-grid { display:grid; grid-template-columns:repeat(auto-fit,minmax(180px,1fr)); gap:14px; }
.score-card { background:var(--branco); border-radius:4px; border:1px solid var(--creme-e); padding:16px; }
.score-card-label { font-size:9.5px; color:var(--dourado); font-weight:600; margin-bottom:3px; letter-spacing:1px; text-transform:uppercase; }
.score-card-drug { font-family:'Cormorant Garamond',serif; font-size:17px; font-weight:500; color:var(--verde); margin-bottom:12px; }
.score-bar-label { font-size:10.5px; color:var(--muted); margin-bottom:5px; }
.score-bar-track { height:4px; background:var(--creme-e); border-radius:2px; overflow:hidden; margin-bottom:4px; }
.score-bar-fill { height:100%; border-radius:2px; transition:width .6s ease; }
.score-bar-fill.high { background:var(--verde); } .score-bar-fill.mid { background:var(--dourado); } .score-bar-fill.low { background:var(--cinza); }
.score-value { font-family:'Cormorant Garamond',serif; font-size:26px; font-weight:500; margin:6px 0 2px; line-height:1; }
.score-value.high { color:var(--verde); } .score-value.mid { color:var(--dourado); } .score-value.low { color:var(--cinza); }
.score-sub { font-size:11px; color:var(--muted); }
.score-divider { height:1px; background:var(--creme-e); margin:10px 0; }

/* TOXICITY */
.tox-list { display:flex; flex-direction:column; gap:8px; }
.tox-item { display:flex; align-items:flex-start; gap:12px; padding:12px 14px; border-radius:3px; border:1px solid transparent; }
.tox-item.g-high { background:var(--coral-bg); border-color:var(--coral-bd); }
.tox-item.g-mid { background:rgba(184,156,121,.07); border-color:rgba(184,156,121,.18); }
.tox-item.g-low { background:rgba(79,87,81,.04); border-color:rgba(79,87,81,.1); }
.tox-rank { width:26px; height:26px; border-radius:2px; display:flex; align-items:center; justify-content:center; font-size:12px; font-weight:700; flex-shrink:0; margin-top:1px; }
.g-high .tox-rank { background:rgba(184,100,30,.15); color:#8B4A14; }
.g-mid .tox-rank { background:rgba(184,156,121,.2); color:#8B6B42; }
.g-low .tox-rank { background:rgba(79,87,81,.12); color:var(--cinza); }
.tox-name { font-size:13.5px; font-weight:500; color:var(--verde); }
.tox-freq { font-size:11.5px; color:var(--muted); margin-top:2px; }
.tox-alert { font-size:12px; margin-top:4px; line-height:1.5; }
.g-high .tox-alert { color:#7A4010; } .g-mid .tox-alert { color:#8B6B42; } .g-low .tox-alert { color:var(--cinza); }
.tox-meta { flex:1; min-width:0; }
.tox-grade { margin-left:auto; padding:2px 8px; border-radius:2px; font-size:10.5px; font-weight:600; flex-shrink:0; white-space:nowrap; margin-top:1px; }
.g-high .tox-grade { background:rgba(184,100,30,.1); color:#8B4A14; }
.g-mid .tox-grade { background:rgba(184,156,121,.15); color:#8B6B42; }
.g-low .tox-grade { background:rgba(79,87,81,.08); color:var(--cinza); }
.tox-select { border:1px solid var(--creme-e); border-radius:3px; padding:6px 10px; font-size:13px; font-family:'Jost',sans-serif; background:white; color:var(--texto); outline:none; }

/* G8 */
.g8-grid { display:grid; grid-template-columns:1fr 1fr; gap:10px; }
.g8-item { background:var(--branco); border-radius:3px; border:1px solid var(--creme-e); padding:12px; }
.g8-item-label { font-size:10px; color:var(--muted); font-weight:600; text-transform:uppercase; letter-spacing:.7px; margin-bottom:5px; }
.g8-select { width:100%; border:1px solid var(--creme-e); border-radius:3px; padding:7px 10px; font-size:12.5px; font-family:'Jost',sans-serif; background:white; color:var(--texto); outline:none; }
.g8-score-display { background:var(--verde); border-radius:4px; padding:16px 20px; display:flex; align-items:center; gap:18px; margin-top:14px; }
.g8-score-number { font-family:'Cormorant Garamond',serif; font-size:52px; font-weight:300; color:var(--dourado-c); line-height:1; }
.g8-score-label { font-size:13px; color:white; font-weight:500; }
.g8-score-sub { font-size:11.5px; color:rgba(230,229,218,.65); margin-top:3px; }
.g8-alert { display:flex; align-items:flex-start; gap:10px; background:rgba(184,100,30,.06); border:1px solid rgba(184,100,30,.15); border-left:3px solid #B8641E; border-radius:0 3px 3px 0; padding:12px 14px; margin-top:12px; font-size:12.5px; color:var(--coral-tx); line-height:1.6; }
.g8-alert i { font-size:15px; flex-shrink:0; margin-top:2px; color:#B8641E; }

/* CONCLUSION */
.conclusion-box { background:var(--branco); border:1px solid var(--creme-e); border-left:3px solid var(--dourado); border-radius:0 4px 4px 0; padding:18px 22px; font-size:13.5px; line-height:1.85; color:var(--texto); font-weight:300; outline:none; min-height:120px; width:100%; font-family:'Jost',sans-serif; resize:vertical; }
.references-box { background:var(--branco); border:1px solid var(--creme-e); border-radius:3px; padding:16px; }
.references-box-label { font-size:9.5px; color:var(--dourado); font-weight:600; letter-spacing:1px; text-transform:uppercase; margin-bottom:10px; }
.references-box ol { font-size:12.5px; line-height:1.9; color:var(--texto); font-weight:300; padding-left:20px; }

/* GUIDELINES LIST */
.guideline-item { display:flex; align-items:center; gap:12px; padding:11px 14px; background:var(--branco); border-radius:3px; border:1px solid var(--creme-e); margin-bottom:8px; }
.guideline-name { font-size:13px; font-weight:500; flex:1; color:var(--verde); }
.guideline-version { font-size:11.5px; color:var(--muted); }
.guideline-ok { padding:3px 9px; border-radius:2px; font-size:10.5px; font-weight:600; background:rgba(24,54,46,.08); color:var(--verde); }
.guideline-update { padding:3px 9px; border-radius:2px; font-size:10.5px; font-weight:600; background:rgba(184,100,30,.08); color:#8B4A14; }

/* BUTTONS */
.btn { display:inline-flex; align-items:center; gap:6px; padding:7px 16px; border-radius:3px; font-size:12.5px; font-weight:500; font-family:'Jost',sans-serif; cursor:pointer; border:1px solid transparent; transition:all .15s; }
.btn-primary { background:var(--verde); color:var(--dourado-c); border-color:var(--verde); }
.btn-primary:hover { background:var(--verde-m); }
.btn-secondary { background:white; color:var(--cinza); border-color:var(--creme-e); }
.btn-secondary:hover { background:var(--branco); border-color:var(--dourado-c); color:var(--verde); }
.btn-gold { background:var(--dourado); color:var(--verde); border-color:var(--dourado); font-weight:600; }
.btn-gold:hover { background:var(--dourado-c); }
.btn-sm { padding:5px 12px; font-size:12px; }
.btn:disabled { opacity:.4; cursor:not-allowed; }

/* TRIALS */
.trial-card { border:1px solid var(--creme-e); border-radius:4px; margin-bottom:10px; overflow:hidden; transition:box-shadow .15s; }
.trial-card:hover { box-shadow:0 2px 8px rgba(24,54,46,.08); }
.trial-card.has-brazil { border-color:rgba(24,54,46,.2); border-left:3px solid var(--verde); }
.trial-card.phase1 { border-left:3px solid var(--cinza); }
.trial-card.phase2 { border-left:3px solid var(--dourado); }
.trial-card.phase3 { border-left:3px solid var(--verde); }
.trial-header { padding:12px 16px; background:var(--branco); display:flex; align-items:flex-start; gap:12px; cursor:pointer; }
.trial-id { font-size:11px; font-weight:600; color:var(--verde); background:rgba(24,54,46,.07); padding:2px 8px; border-radius:2px; white-space:nowrap; }
.trial-source { font-size:10px; color:var(--muted); background:var(--creme); padding:2px 7px; border-radius:2px; white-space:nowrap; }
.trial-title { font-size:13px; font-weight:500; color:var(--texto); flex:1; line-height:1.4; }
.trial-phase-badge { font-size:10.5px; font-weight:600; padding:2px 8px; border-radius:2px; white-space:nowrap; }
.phase-badge-1 { background:rgba(79,87,81,.08); color:var(--cinza); }
.phase-badge-2 { background:rgba(184,156,121,.12); color:#8B6B42; }
.phase-badge-3 { background:rgba(24,54,46,.08); color:var(--verde); }
.trial-brazil-flag { display:flex; align-items:center; gap:5px; font-size:11px; font-weight:600; color:var(--verde); background:rgba(24,54,46,.07); padding:2px 8px; border-radius:2px; white-space:nowrap; }
.trial-body { padding:0 16px 14px; }
.trial-body-inner { display:grid; grid-template-columns:1fr 1fr; gap:12px; padding-top:10px; border-top:1px solid var(--creme-e); }
.trial-field-label { font-size:9.5px; color:var(--dourado); font-weight:600; letter-spacing:.8px; text-transform:uppercase; margin-bottom:3px; }
.trial-field-value { font-size:12.5px; color:var(--texto); line-height:1.5; }
.trial-centers { margin-top:10px; }
.trial-center-item { display:flex; align-items:flex-start; gap:8px; padding:8px 10px; background:rgba(24,54,46,.04); border-radius:3px; margin-bottom:6px; border-left:2px solid var(--verde); }
.trial-center-item i { font-size:14px; color:var(--verde); flex-shrink:0; margin-top:2px; }
.trial-center-name { font-size:12.5px; font-weight:500; color:var(--verde); }
.trial-center-contact { font-size:11.5px; color:var(--muted); margin-top:2px; }
.trial-center-email { font-size:11.5px; color:var(--dourado); }
.trial-intl { font-size:11.5px; color:var(--muted); }
.trial-relevance { display:flex; align-items:center; gap:6px; margin-bottom:6px; }
.relevance-dot { width:8px; height:8px; border-radius:50%; flex-shrink:0; }
.relevance-high { background:var(--verde); }
.relevance-mid { background:var(--dourado); }
.relevance-low { background:var(--cinza); }
.relevance-text { font-size:11.5px; color:var(--muted); }
.trial-stats-bar { display:flex; gap:16px; padding:10px 16px; background:var(--verde); border-radius:4px; align-items:center; }
.trial-stat { text-align:center; }
.trial-stat-num { font-family:'Cormorant Garamond',serif; font-size:24px; font-weight:400; color:var(--dourado-c); line-height:1; }
.trial-stat-label { font-size:10px; color:rgba(230,229,218,.65); letter-spacing:.5px; text-transform:uppercase; margin-top:2px; }
.trial-stat-divider { width:1px; height:32px; background:rgba(255,255,255,.1); }
.trial-filter-label { display:flex; align-items:center; gap:5px; font-size:12.5px; color:var(--cinza); cursor:pointer; }
.trial-filter-label input { accent-color:var(--verde); }
.trial-toggle { margin-left:auto; font-size:11.5px; color:var(--dourado); cursor:pointer; white-space:nowrap; }
.empty-state { text-align:center; padding:32px 20px; color:var(--muted); }
.empty-state i { font-size:36px; display:block; margin-bottom:10px; opacity:.4; }
.empty-state p { font-size:13px; }

/* NOTIF */
.notif { display:flex; align-items:flex-start; gap:10px; padding:11px 16px; border-radius:0 3px 3px 0; font-size:12.5px; margin-bottom:16px; }
.notif.warning { background:rgba(184,100,30,.06); color:var(--coral-tx); border-left:3px solid #B8641E; }
.notif i { font-size:15px; flex-shrink:0; margin-top:1px; }